Synonyms for mono Found 6 synonyms across 2 meanings for “mono”. an acute disease characterized by fever and swollen lymph nodes and an abnormal increase of mononuclear leucocytes or monocytes in the bloodstream (noun) mononucleosis designating sound transmission or recording or reproduction over a single channel (adj) monophonicsingle-channel Explore Related Words Rhymes with monoSynonyms for mononucleosisSynonyms for monophonicSynonyms for single-channel Synonym Finder | Rhyme Finder | Poetry Editor